Peptide Protocol IQ
Stack directory

Peptide stacks, graded on the combination rather than the parts

A stack is not the sum of its compounds. Two well-evidenced compounds administered together are a third thing that nobody has necessarily studied, and the grade on every card below describes the combination itself.

It is worth knowing how rarely that grade is high. Of the 11 stacks here, 1 carries human trial evidence for the pairing. The rest are built from what each compound did on its own, plus a mechanistic argument for putting them together, and this site will not present that as more than it is.

What the grade on a stack means

A grade of A or B on a stack requires a verified human trial in which those compounds were administered together, and in which every compound in the phase appears. Citing each part separately does not qualify, and a build-time test enforces it. CagriSema is currently the only stack on this site that clears that bar.

Start from the goal

Complexity counts compounds, not difficulty. Every additional compound is another vial, another reconstitution, another injection site and one more thing that cannot be attributed if something changes.

If the goal isStackCompoundsComplexityCombination evidence
Soft-tissue and tendon repairWolverine StackBPC-157 + TB-500Low · 2D · Preclinical
Growth-hormone axis researchCJC-1295 + IpamorelinCJC-1295 (no DAC / Mod GRF 1-29) + IpamorelinLow · 2D · Preclinical
Body recomposition supportRecomp StackBPC-157 + CJC-1295 / Ipamorelin blend + AOD-9604 + GHK-Cu + DSIPHigher · 5D · Preclinical
Soft-tissue repair with a dermal componentGLOW StackBPC-157 + TB-500 + GHK-CuMedium · 3D · Preclinical
Soft-tissue repair with an anti-inflammatory componentKLOW StackBPC-157 + TB-500 + GHK-Cu + KPVHigher · 4D · Preclinical
Chronic weight managementCagriSemaCagrilintide + SemaglutideLow · 2A · Strong
Chronic weight managementCagrilintide + TirzepatideCagrilintide + TirzepatideLow · 2X · Insufficient / conflicting
Chronic weight managementCagrilintide + RetatrutideRetatrutide + CagrilintideLow · 2X · Insufficient / conflicting
Weight management with a mitochondrial componentRetatrutide + MOTS-cRetatrutide + MOTS-cLow · 2X · Insufficient / conflicting
Growth hormone axis supportTesamorelin + IpamorelinTesamorelin + IpamorelinLow · 2D · Preclinical
Anxiety and cognitive supportRussian Nootropic StackSemax + SelankLow · 2X · Insufficient / conflicting

Browse the stacks

Browse protocols

11 protocols, every one of them a real page. Nothing here is a placeholder.

Cognitive & focus

Nootropic and neuropeptide protocols.

Growth hormone axis

Secretagogues and releasing hormones acting on growth hormone.

Tissue repair & recovery

Soft tissue, tendon and injury protocols. Heavily used, thinly evidenced.

Weight & metabolic

Incretin agonists and metabolic compounds. The best-evidenced group on the site.

Why stacks are graded lower than their compounds

Tirzepatide has a large approved trial programme. Cagrilintide has a phase 2 dose-finding study. Putting them in the same week is a pairing with no trial at all, and no amount of evidence about either compound alone changes that. This is the most common error in the category and it is usually made in good faith: the compounds are well studied, so the stack feels well studied.

The exception proves the point. CagriSema is graded A because REDEFINE 1 randomised 3,417 people to that exact pairing at those exact amounts for 68 weeks. That is what evidence for a combination looks like, and it is worth having one page on the site that shows what the others are being measured against.

The second thing a stack multiplies is cost. Every compound is a separate vial with its own minimum purchase, and a vial that cannot be finished before its reconstituted shelf life is still a vial you bought. The cost table on each page simulates that rather than dividing milligrams.